In the healthy brain ATP is constantly synthesised to maintain the demand for energy for cells to work properly
Bodily tissues such as the brain rely on a constant source of blood to fuel cellular work. Acute traumatic injuries, be they haemorrhagic (bleeds), ischaemic (blocks) or severe inflammation, disrupt the supply of blood to tissue resulting in cells being starved of oxygen (hypoxia). This results in the breakdown of the fuel molecule to its constituents – the purines. Purines therefore offer the potential of a highly effective biomarker as they are produced within minutes of the onset of hypoxia/ischaemia and prior to any irreversible cellular damage.
Our technology will enable purines to be used as a biomarker, not only for stroke but also for, traumatic brain injury (TBI), heart attacks (MI), foetal hypoxia and sepsis where symptoms for each are complex with many confounding mimics and where existing diagnostic solutions fall short of the clinical needs.
Our innovative diagnostic solution is geared to:
During a stroke, the absence of oxygen and glucose means that ATP is not resynthesized. Instead, it is broken down into its components – the purines. The purines in the green box are detected by Sarissa’s SMARTChip giving a rapid diagnosis of the occurrence of a stroke.